The present study involves the formulation and evaluation of oro-dispersible films of amlodipine besylate. In this research work three film formulations F1, F2, F3 were prepared consisting of drug alone, drug with super-disintegrant cross carmellose sodium, solid dispersion of the drug in PEG 6000 respectively using HPMC and propylene glycol. The films were fabricated by solvent casting method using amlodipine besylate, an anti hypertensive drug, undergoes the hepatic degradation of about 30% with half life 30-50 hrs. Buccal route is an excellent alternative method systemic drug delivery that can overcome the hepatic first pass effect and improve the bioavailability and therapeutic efficacy. Four formulations of solid dispersions SD1 – SD4 were prepared using two different ratios of polymer and two different methods of preparation. The optimized formulation of solid dispersion of drug was used in the film formulation F3. The formulations were evaluated for various physicochemical parameters along with in-vitro drug release studies. The study concluded that formulation F3 was the best formulation which follows first order release kinetics with R2 value 0.976. Drug delivery through oro-dispersible films provides many advantages compared to conventional dosage forms. This route can be further recommended for future development.
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